Structure of PDB 6jij Chain A Binding Site BS01

Receptor Information

>6jij Chain A (length=297) Species: 11142 (Murine hepatitis virus strain A59)

SGIVKMVSPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSDMTDP
DYPNLLCRVTSSDFCVMSGRMSLTVMSYQMQGCQLVLTVTLQNPNTPKYS
FGVVKPGETFTVLAAYNGRPQGAFHVTLRSSHTIKGSFLCGSCGSVGYVL
TGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTV
NVVAWLYAAIFNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLVLDALA
SMTGVTVEQVLAAIKRLHSGFQGKQILGSCVFEDELTPSDVYQQLAG

Ligand information

>6jij Chain F (length=5) Species: 32630 (synthetic construct)

gAVLa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6jij The crystal structure of main protease from mouse hepatitis virus A59 in complex with an inhibitor.
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): F138 G141 C143 H161 Q162 L163 E164 Q187 V188 V189
• Binding residue (residue number reindexed from 1): F138 G141 C143 H161 Q162 L163 E164 Q187 V188 V189

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:6jij, PDBe:6jij, PDBj:6jij
• PDBsum: 6jij
• PubMed: 30833083
• UniProt: P0C6X9|R1AB_CVMA5 Replicase polyprotein 1ab (Gene Name=rep)