Structure of PDB 6j7x Chain A Binding Site BS01
Receptor Information
>6j7x Chain A (length=276) Species:
9606
(Homo sapiens) [
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EVAVLVQRVVKDITNAFRRNPHIDEIGLIPCPEARYNRSPIVLVENKLGV
ESWCVKFLLPYVHNKLLLYRTRKQWLNRDELIDVTCTLLLLNPDFTTAWN
VRKELILSGTLNPIKDLHLGKLALTKFPKSPETWIHRRWVLQQLIQTIPT
ERAQRLIQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHLAKLDVKILLDEL
SSTKHWASMHVSDHSGFHYRQFLLKSLISQTVEPRINLPHLLEEEVEFST
DLIDSYPGHETLWCHRRHIFYLQHHL
Ligand information
Ligand ID
GRG
InChI
InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
InChIKey
OINNEUNVOZHBOX-QIRCYJPOSA-N
SMILES
Software
SMILES
CACTVS 3.385
CC(C)=CCCC(/C)=C/CC\C(C)=C\CC\C(C)=C\CO[P](O)(=O)O[P](O)(O)=O
CACTVS 3.385
CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO[P](O)(=O)O[P](O)(O)=O
OpenEye OEToolkits 1.7.5
CC(=CCCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C)C
OpenEye OEToolkits 1.7.5
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO[P@](=O)(O)OP(=O)(O)O)/C)/C)/C)C
ACDLabs 10.04
O=P(O)(O)OP(=O)(O)OC/C=C(/CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)C)C
Formula
C20 H36 O7 P2
Name
GERANYLGERANYL DIPHOSPHATE
ChEMBL
CHEMBL1229266
DrugBank
ZINC
ZINC000012495043
PDB chain
6j7x Chain B Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
6j7x
Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
Resolution
2.75 Å
Binding residue
(original residue number in PDB)
K135 Y195
Binding residue
(residue number reindexed from 1)
K129 Y175
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0008318
protein prenyltransferase activity
Biological Process
GO:0018342
protein prenylation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:6j7x
,
PDBe:6j7x
,
PDBj:6j7x
PDBsum
6j7x
PubMed
UniProt
Q7Z6K3
|PTAR1_HUMAN Protein prenyltransferase alpha subunit repeat-containing protein 1 (Gene Name=PTAR1)
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