Structure of PDB 6j5x Chain A Binding Site BS01

Receptor Information
>6j5x Chain A (length=280) Species: 1718 (Corynebacterium glutamicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLATIRTNGTTIAARVESENTATTIEGFANVGELLQESNWRELAENAAG
EAVTFENKELDAVVPAPKKIVCVGLNYANHIKEMGRDLPDTPTLFVKFPD
ALIGPFDDVVVPEWANKALDWEGEMAVIIGKRARRVKQADAAEYIAGYAV
MNDYTTRDFQYAAPAKTPQWHQGKSLEKSAGFGPWMTTPDSFEFGGELAT
YLEGEKVQSTPTNDLVFSPEKLIEYITHIYPLDAGDVIVTGTPGGVGHAR
NPQRYIGDGETVKVEIAGLGFIENKTVFEL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6j5x Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6j5x Sequence, structure and function-based classification of the broadly conserved FAH superfamily reveals two distinct fumarylpyruvate hydrolase subfamilies.
Resolution1.79 Å
Binding residue
(original residue number in PDB)
E122 E124 D153
Binding residue
(residue number reindexed from 1)
E122 E124 D153
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.-
5.3.3.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018773 acetylpyruvate hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6j5x, PDBe:6j5x, PDBj:6j5x
PDBsum6j5x
PubMed31657110
UniProtQ8NLC0

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