Structure of PDB 6j4x Chain A Binding Site BS01

Receptor Information
>6j4x Chain A (length=1411) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKHI
SPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTH
KLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQA
LQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQV
GVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRID
LRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMP
YSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSP
QSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPA
ILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMF
GVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSI
GIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESF
EGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSAC
VGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFF
FHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDII
QFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIE
YAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRRI
IQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQN
ATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEM
VGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIAL
DIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSQ
SPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLII
RCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYK
NEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLY
KEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALMR
CSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKL
LTSLPADYAPT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6j4x Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		A252 M253 Y418 D486
Binding residue
(residue number reindexed from 1)		A237 M238 Y403 D471
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j4x, PDBe:6j4x, PDBj:6j4x
PDBsum6j4x
PubMed30733384
UniProtC4R4Y0

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