Structure of PDB 6izm Chain A Binding Site BS01

Receptor Information
>6izm Chain A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDL
NDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFG
DFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQD
NLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTET
DMSLHPLLQEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB6izm Structure-Activity Relationship Studies of 3- or 4-Pyridine Derivatives of DS-6930.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		K301 L311 N312 Q314 V315 L318 L468 E471
Binding residue
(residue number reindexed from 1)		K90 L100 N101 Q103 V104 L107 L257 E260
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6izm, PDBe:6izm, PDBj:6izm
PDBsum6izm
PubMed30891140
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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