Structure of PDB 6iw6 Chain A Binding Site BS01

Receptor Information
>6iw6 Chain A (length=438) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCR
YLCKLCLIHIENIQGAHKHIKEKRHKKNILEKQEESELRSLPPPSPAHLA
ALSVAVIELAKEHGITDDDLRVRQEIVEEMSKVITTFLPECSLRLYGSSL
TRFALKSSDVNIDIKFPPKMNHPDLLIKVLGILKKNVLYVDVESDFHAKV
PVVVCRDRKSGLLCRVSAGNDMACLTTDLLTALGKIEPVFIPLVLAFRYW
AKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIEGFDPKR
MDDFQLKGIVEEKFVKWECNSSSATKEKHGKSPLALETPNRVSLGQLWLE
LLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIEDPFSVKRNVAR
SLNSQLVYEYVVERFRAAYRYFACPQVDFKLEHHHHHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6iw6 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6iw6 Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression.
Resolution2.402 Å
Binding residue
(original residue number in PDB)		C306 C309 H322 H328
Binding residue
(residue number reindexed from 1)		C53 C56 H69 H75
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0016779 nucleotidyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6iw6, PDBe:6iw6, PDBj:6iw6
PDBsum6iw6
PubMed31036859
UniProtQ5TAX3|TUT4_HUMAN Terminal uridylyltransferase 4 (Gene Name=TUT4)

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