Structure of PDB 6ivj Chain A Binding Site BS01

Receptor Information
>6ivj Chain A (length=269) Species: 573 (Klebsiella pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSKIIFRLLLNVLMSIIAIISYQWYEQLGIHLTVAPFSLLGIAIAIFLGF
RNSASYSRFVEARNLWGTVLIAERTLVRQLRNILPAEHDAHRRIVSYLVA
FSWSLKHQLRKTDPTADLRRLLPEERVTEILASSMPTNRILLLAGNEIGQ
LREAGKLSDITYGLMDNKLDELAHVLGGCERLATTPVPFAYTLILQRTVY
LFCTLLPFALVGDLHYMTPFVSVFISYTFLSWDSLAEELEDPFGTAANDL
PLNAMCNTIERNLLDMTGQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ivj Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ivj Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Resolution2.77 Å
Binding residue
(original residue number in PDB)		H108 H111
Binding residue
(residue number reindexed from 1)		H88 H91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005254 chloride channel activity
Biological Process
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ivj, PDBe:6ivj, PDBj:6ivj
PDBsum6ivj
PubMed31263784
UniProtW9BH30

[Back to BioLiP]