Structure of PDB 6iv5 Chain A Binding Site BS01

Receptor Information

>6iv5 Chain A (length=334) Species: 3702 (Arabidopsis thaliana)

MEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKN
DRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPK
RSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVRKKIYVRLLLSIDRRETTE
SAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITL
HCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSN
IVTKSISSIDIHHFADLYNAKHPLILCTDDFGVFSTSLSNEYALAVRSLG
LSKSETFALARAAIDATFAEDEVKQQLRFIFDSA

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 6iv5 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6iv5 Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.
• Resolution: 1.749 Å
• Binding residue (original residue number in PDB): N17 H65 T97 T98 K100
• Binding residue (residue number reindexed from 1): N17 H65 T97 T98 K100
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.4.-

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0019239 deaminase activity
• GO:0046872 metal ion binding
• GO:0062154 N6-methyl-AMP deaminase activity

Biological Process

• GO:0006401 RNA catabolic process
• GO:0009117 nucleotide metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6iv5, PDBe:6iv5, PDBj:6iv5
• PDBsum: 6iv5
• PubMed: 31318636
• UniProt: Q8LPL7|ADAL_ARATH N6-mAMP deaminase (Gene Name=MAPDA)