Structure of PDB 6iu7 Chain A Binding Site BS01
Receptor Information
>6iu7 Chain A (length=422) Species:
10090
(Mus musculus) [
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NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF
Ligand information
>6iu7 Chain B (length=22) Species:
9606
(Homo sapiens) [
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SGKRKLITSEEERSPAKRGRKS
Receptor-Ligand Complex Structure
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PDB
6iu7
Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
S105 F138 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 W231 R238 D270 W273 Y277 G281 R315 V321 T322 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)
S31 F64 W68 N72 S75 G76 T77 T81 Q107 W110 N114 G117 D118 W157 R164 D196 W199 Y203 G207 R241 V247 T248 W283 N287 E322 W325
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6iu7
,
PDBe:6iu7
,
PDBj:6iu7
PDBsum
6iu7
PubMed
30685087
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
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