Structure of PDB 6is0 Chain A Binding Site BS01

Receptor Information
>6is0 Chain A (length=467) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VYWDLDIQTNAVIRERAPADHLPPHPEIELQRAQLTTKLRQHYHELCSQR
EGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIPI
RLSRIKYKEEARKLLFKYAEAAKKMIDSRNVTPESRKVVKWNVEDTMNWL
RRDHSASKEDYMDRLENLRKQCGPHVASVAKDSVEGICSKIYHISAEYVR
RIRQAHLTLLKECNISVDGEVQDRLVYCYPVRLSIPAPPQTRVELHFEND
IACLRFKGEMVKVSRGHFNKLELLYRYSCIDDPRFEKFLSRVWCLIKRYQ
VMFGSGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFCSAFPDIDGFFG
SRGPFLSFSPASGSFEANPPFCEELMDAMVTHFEDLLGRSSEPLSFIIFV
PEWRDPPTPALTRMEASRFRRHQMTVPAFEHEYRSHGTAVIFLQNNAGFA
KWEPTTERIQELLAAYK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6is0 Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		V178 Y179 R446 E622 R624
Binding residue
(residue number reindexed from 1)		V1 Y2 R265 E432 R434
Enzymatic activity
Enzyme Commision number 2.1.1.62: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0099122 RNA polymerase II C-terminal domain binding

View graph for
Molecular Function
External links
PDB RCSB:6is0, PDBe:6is0, PDBj:6is0
PDBsum6is0
PubMed30467178
UniProtA0A0R4IKJ1|CAPAM_DANRE mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (Gene Name=pcif1)

[Back to BioLiP]