Structure of PDB 6imn Chain A Binding Site BS01

Receptor Information

>6imn Chain A (length=411) Species: 10497 (African swine fever virus)

MLNQFPGQYSNNIFCFPPIESETKSGKKASWIICVQVVQHNTIIPITDEM
FSTDVKDAVAEIFTKFFVEEGAVRISKMTRVTEGKNLGKKNATTVVHQAF
KDALSKYNRHARQKRGNRGMIPPMLVKYFNIIPKTFFEEETDPIVQRKRN
GVRAVACQQGDGCILLYSRTEKEFLGLDNIKKELKQLYLFIDVRVYLDGE
LYLHRKPLQWIAGQANAKTDSSELHFYVFDCFWSDQLQMPSNKRQQLLTN
IFKQKEDLTFIHQVENFSVKNVDEALRLKAQFIKEGYEGAIVRNANGPYE
PGYNNYHSAHLAKLKPLLDAEFILVDYTQGKKGKDLGAILWVCELPNKKR
FVVTPKHLTYADRYALFQKLTPALFKKHLYGKELTVEYAELSPKTGIPLQ
ARAVGFREPIN

Ligand information

>6imn Chain F (length=22)

ccagtccgacccgcatcccgga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6imn Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): T23 K24 W31 F66 K89 K90 N91 Q212 G216 A220 N307 Y309 K334 K335 F354 V355 S395 K397 T398 L402
• Binding residue (residue number reindexed from 1): T23 K24 W31 F66 K89 K90 N91 Q209 G213 A217 N304 Y306 K331 K332 F351 V352 S392 K394 T395 L399

Enzymatic activity

• Enzyme Commision number: 6.5.1.1: DNA ligase (ATP).

Gene Ontology

Molecular Function

• GO:0003909 DNA ligase activity
• GO:0003910 DNA ligase (ATP) activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair
• GO:0006310 DNA recombination
• GO:0051301 cell division

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6imn, PDBe:6imn, PDBj:6imn
• PDBsum: 6imn
• PubMed: 30674878
• UniProt: P35970|DNLI_ASFB7 DNA ligase (Gene Name=LIG)