Structure of PDB 6iml Chain A Binding Site BS01

Receptor Information

>6iml Chain A (length=403) Species: 10497 (African swine fever virus)

MLNQFPGQYSNNIFCFPPIESETKSGKKASWIICVQVVQHNTIIPITDEM
FSTDVKDAVAEIFTKFFVEEGAVRISKMTRVTEGKNLGKKNATTVVHQAF
KDALSKYNRHARQKRGMIPPMLVKYFNIIPKTFFEEETDPIVQRKRNGVR
AVACQQGDGCILLYSRTEKEFLGLDNIKKELKQLYLFIDVRVYLDGELYL
HRKPLQWIAGQANAKTDSSELHFYVFDCFWSDQLQMPSNKRQQLLTNIFK
QKEDLTFIHQVENFSVKNVDEALRLKAQFIKEGYEGAIVRNANGPYEPGY
NNYHSAHLAKLKPLLDAEFILVDYTQGKKGKDLGAILWVCELPNKKRFVV
TPKHLTYADRYALFQKLTPALFKKHLYGKELTVEYAELSPKTGIPLQARA
VGF

Ligand information

>6iml Chain C (length=22)

ccagtccgacccgcatcccgga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6iml Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): T23 K24 W31 F66 K89 K90 K130 Q212 G216 A220 K221 N307 Y309 K334 K335 G336 K337 D338 V355 S395 T398
• Binding residue (residue number reindexed from 1): T23 K24 W31 F66 K89 K90 K124 Q206 G210 A214 K215 N301 Y303 K328 K329 G330 K331 D332 V349 S389 T392

Enzymatic activity

• Enzyme Commision number: 6.5.1.1: DNA ligase (ATP).

Gene Ontology

Molecular Function

• GO:0003909 DNA ligase activity
• GO:0003910 DNA ligase (ATP) activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair
• GO:0006310 DNA recombination
• GO:0051301 cell division

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6iml, PDBe:6iml, PDBj:6iml
• PDBsum: 6iml
• PubMed: 30674878
• UniProt: P35970|DNLI_ASFB7 DNA ligase (Gene Name=LIG)