Structure of PDB 6ika Chain A Binding Site BS01 |
| >6ika Chain A (length=553) Species: 11676 (Human immunodeficiency virus 1)
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PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KQKKSVTVLDVSAAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLP
MGWKGSPALLQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRET
KLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQ
YALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS |
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| PDB | 6ika Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. |
| Resolution | 2.598 Å |
Binding residue
(original residue number in PDB) | W24 F61 L74 D76 R78 E89 I94 G152 K154 P157 Y183 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 K374 R448 T473 Q475 Y501 |
Binding residue
(residue number reindexed from 1) | W24 F61 L74 D76 R78 E89 I94 G152 K154 P157 Y183 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 K374 R448 T473 Q475 Y501 |
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| Enzyme Commision number |
3.1.26.13: retroviral ribonuclease H. |
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