Structure of PDB 6ijr Chain A Binding Site BS01

Receptor Information
>6ijr Chain A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP
FVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEI
TEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQG
FMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGD
RPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIV
TEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB6ijr Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		Q314 V315 K319 L468 E471
Binding residue
(residue number reindexed from 1)		Q118 V119 K123 L272 E275
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ijr, PDBe:6ijr, PDBj:6ijr
PDBsum6ijr
PubMed31371757
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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