Structure of PDB 6iih Chain A Binding Site BS01

Receptor Information
>6iih Chain A (length=446) Species: 9606,10665 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSIWYNQTPNRAKRVI
TTFRTGTWDAYHMLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMTSV
KKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPH
SGFHVAFKMLDTDGNEMIEKREFFKLINTTLQMRFFGKRGQRKLHYKEFR
RFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTENKDIYWKNV
REKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRA
VKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6iih Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6iih The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation.
Resolution1.958 Å
Binding residue
(original residue number in PDB)		D264 D266 N268 M270 E275
Binding residue
(residue number reindexed from 1)		D261 D263 N265 M267 E272
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6iih, PDBe:6iih, PDBj:6iih
PDBsum6iih
PubMed31397067
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
Q8IYU8|MICU2_HUMAN Calcium uptake protein 2, mitochondrial (Gene Name=MICU2)

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