Structure of PDB 6icv Chain A Binding Site BS01

Receptor Information
>6icv Chain A (length=480) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPKEILNLTSELLQKCSSPAPGKEWEEYVQIRTLVEKIRKKQKGLSVTFD
GKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLW
VPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFW
QPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYK
VIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIP
LWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFV
IHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHF
TEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDN
EVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEK
EILEKAVKSAAVNREYYRQQMEEKAPLPKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6icv Structural insights into SETD3-mediated histidine methylation on beta-actin.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		S37 M152 N154 I155 R215 Q216 V248 V251 Q255 N256 P259 W274 D275 T286 G287 Y288 Y313 R316 H324
Binding residue
(residue number reindexed from 1)		S17 M130 N132 I133 R193 Q194 V226 V229 Q233 N234 P237 W252 D253 T264 G265 Y266 Y291 R294 H302
Enzymatic activity
Enzyme Commision number 2.1.1.85: protein-histidine N-methyltransferase.
Gene Ontology
Molecular Function
GO:0018064 protein-L-histidine N-tele-methyltransferase activity
Biological Process
GO:0030047 actin modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6icv, PDBe:6icv, PDBj:6icv
PDBsum6icv
PubMed30785395
UniProtQ86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

[Back to BioLiP]