Structure of PDB 6icj Chain A Binding Site BS01

Receptor Information

>6icj Chain A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTKSPFVIYDMNSLMM
GEKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV
HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV
KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLK
LNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEI
YKDL

Ligand information

>6icj Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ERHKILHRLLQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6icj Crystal structure of PPARgamma with compound BR102375K
Resolution	2.483 Å
Binding residue (original residue number in PDB)	K301 Q314 V315 K319 L468 E471
Binding residue (residue number reindexed from 1)	K79 Q92 V93 K97 L246 E249

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6icj, PDBe:6icj, PDBj:6icj
PDBsum	6icj
PubMed
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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