Structure of PDB 6ibo Chain A Binding Site BS01

Receptor Information

>6ibo Chain A (length=695) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ
GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI
NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQ
IVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIA
ERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGKHPTSHLM
QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKA
ADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFM
DYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFK
SIYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMINR
GQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAI
VYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQN
MGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTP
MVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKK
VRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI

Ligand information

>6ibo Chain C (length=5) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AVSRA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6ibo Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.
Resolution	2.17 Å
Binding residue (original residue number in PDB)	H506 H509 P569 T643 K644
Binding residue (residue number reindexed from 1)	H182 H185 P245 T319 K320

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:6ibo, PDBe:6ibo, PDBj:6ibo
PDBsum	6ibo
PubMed	31296563
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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