Structure of PDB 6i8a Chain A Binding Site BS01

Receptor Information
>6i8a Chain A (length=1107) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVN
DVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLF
EARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFRDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDS
IKAETCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNLTFDELSY
ADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFR
DRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILN
SFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDG
IWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKD
PLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSL
AELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLD
VLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLG
EDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTL
DPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPD
WLKRKIA
Ligand information
Receptor-Ligand Complex Structure
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PDB6i8a Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.652 Å
Binding residue
(original residue number in PDB)		P433 Q434 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1051 M1052 S1053 Y1059 Q1062
Binding residue
(residue number reindexed from 1)		P375 Q376 D797 T798 K889 Y891 K904 G905 K909 R910 R911 S973 M974 S975 Y981 Q984
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6i8a, PDBe:6i8a, PDBj:6i8a
PDBsum6i8a
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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