Structure of PDB 6hzn Chain A Binding Site BS01

Receptor Information
>6hzn Chain A (length=743) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ITDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTE
AVHTMLSSPLEYLPPWDPKDYSARWNEIFGNNLGALAMFCVLYPENIEAR
DMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQ
QEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQ
GYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYM
FLVQRHFNINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPE
SQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLW
YDGSLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLG
GRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALY
GPKYTFFNNVLMFSPAVSKSCFSPWVGQVTEDCSSKWSKYKHDLAASCQG
RVVAAEEKNGVVFIRGEGVGAYNPQLNLKNVQRNLILLHPQLLLLVDQIH
LGEESPLETAASFFHNVDVPFEETVVDGVHGAFIRQRDGLYKMYWMDDTG
YSEKATFASVTYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSIDVQS
FTVHGDSQQLDVFIATSKHAYATYLWTGEATGQSAFAQVIADRHKILFDR
NSAIKSSIVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVRN
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6hzn Chain A Residue 810 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hzn The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
Resolution2.41 Å
Binding residue
(original residue number in PDB)		H452 E470 N481
Binding residue
(residue number reindexed from 1)		H429 E447 N458
Annotation score1
Enzymatic activity
Enzyme Commision number 5.1.3.19: chondroitin-glucuronate 5-epimerase.
External links
PDB RCSB:6hzn, PDBe:6hzn, PDBj:6hzn
PDBsum6hzn
PubMed
UniProtQ9UL01|DSE_HUMAN Dermatan-sulfate epimerase (Gene Name=DSE)

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