Structure of PDB 6hzf Chain A Binding Site BS01

Receptor Information
>6hzf Chain A (length=860) Species: 732242 (Phocaeicola paurosaccharolyticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVNVVMTGDMTTRLAFAGEQLKQALVEKGYEVNQTTGKRSIYLNLLNDTT
KKNKERFDISTKGKNTYVTGYDGNGIIYGCRELIDQLDQSGTMDFKPVSD
APEMVLRGACIGLQKTTYLPGHAVYEYPYTPESFPWFYDKERWIKYLDMM
VENRMNSLYLWNGHPFASLVKLKDYPFALEVDEETFKKNEEMFSFLTTEA
EKRGIFVIQMFYNIIVSKPFADHYGIKTQDRNRPITPLISDYTRKSVAAF
IEKYPNVGLLVCLGEAIGTYEEDVEWFTKTIIPGIKDGLKVLGRTDEPPV
LVRAHDTDCKMVIDAALPLYKNLYTMHKYNGESLTTYEPRGPWAKIHKDL
SSLGSVHISNVHILANLEPWRWSSPDFIQKSVKAMHSVHGANALHIYPQA
NYWDWPYTADKLANGEREEQVYRDWAWYKAWGRYAWKADRNRLEEIKYWD
KQFGDFYGIPAEMADNIRIAYEESGEIAPKLLRRFGITEGNRQTLLLGMF
MSQFVNPYKYTIHYGFYESCGPGGEKLIEYVEKEWKKQPHVGELPLDIIN
QVIEHGDKAVAAIDKVVSSAKKNSDELRRLQNDMHCYREYAYAFYYKVKA
AQHVLNYHWGKNMDELDKAVPLMEESLKHYTKLVDLTKDTYLFANSMQTA
QRRIPIGGDDGNNKTWSEMLVHYKAELYNFKENIEMLKDKKVRKCVEVTP
LKEADVKILNNLTKVKIEKGAKIFSNIDGGIDAIAKEITGLTGFVFNGEK
QRDDATTIEFECSSPVTMLVAYFKDDHRKFAKAPRLESDASANDYGQAEP
VLTNALHVKGVALADIYPYKFKAGRHTLILPKGYCGVLGFTEDKIKERDV
ALDAPDWLFY
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain6hzf Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hzf Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		Y154 Y241 E294 R332 H334 K357 E361 H391
Binding residue
(residue number reindexed from 1)		Y125 Y212 E265 R303 H305 K328 E332 H362
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hzf, PDBe:6hzf, PDBj:6hzf
PDBsum6hzf
PubMed30877196
UniProtA0A4V8GZY3

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