Structure of PDB 6hwj Chain A Binding Site BS01

Receptor Information

>6hwj Chain A (length=428) Species: 235985 (Streptacidiphilus jiangxiensis)

MTPNWSELVAAADPALVLPSGERRAEVAVPGPLRLDALLDLGEGHAVGVV
RSADAARWTVPLVRDGAGGVRRSRPGDGTAEHLVAALARDAAFVLEAFTG
AAPVTGERGIIVDESVIVGECAVVKWAVRLPAEGEPGSPAAQRIAALARG
GFTEMPRPWGLLTLAEGAQPVLLASVVAYLPGALDGWDWAVDDVRRLARG
ELTMDQALLPAAQLGTLTARMHAALAARGRTPATAADVAAWGVRMREELD
EAVASVPGAEGERLKAWAPRIADVYAELDALAGTPLIDVHGDFHVGQILR
ADGRYAVVDFDGNPVLPADQRAARQPAALDVVGMTASLDHVGRVVVFRTP
DVDPAPVRAWIAAAQRSFLDAYRTTLARLDADDLFDDRLLTPLRYAQEVR
EYLYAVRHLPHWVYVPDLSLTDLLPERL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6hwj Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hwj Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.
• Resolution: 1.979 Å
• Binding residue (original residue number in PDB): Q305 D317
• Binding residue (residue number reindexed from 1): Q297 D309
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.8: glucosamine kinase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding
• GO:0047931 glucosamine kinase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0016310 phosphorylation

External links

• PDB: RCSB:6hwj, PDBe:6hwj, PDBj:6hwj
• PDBsum: 6hwj
• PubMed: 31088917
• UniProt: A0A1H7TQR5|GLCNK_STRJI Glucosamine kinase (Gene Name=SAMN05414137_114149)