Structure of PDB 6hlr Chain A Binding Site BS01

Receptor Information
>6hlr Chain A (length=1458) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITDISSTLLNEL
KSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRG
KCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGSTYILSTEVKNIL
DTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKLG
EEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLLEDRRVIFSRLMNAFVTI
QNDVNAFIDSTKAQGVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVIS
PDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQ
IQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRD
VVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNM
HFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDS
FFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGKQIITTV
LLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGILDKSQ
YGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRL
TAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRD
NNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKG
SNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGR
FYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYD
NSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKYNPSAL
IEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGS
VSENFQDKLESFLDKNSKGVNEKKFRALMQLKYMRSLINPGEAVGIIASQ
SVGEPSTQMTLNVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQAD
TFCKSISKVLLSEVIDKVIVTETTGARSYVIHMRFFDNNEYSEEYDVSKE
ELQNVISNQFIHLLEAAIVKEIKKQKRVEANNNMNKVQRDRQSAIISHHR
FITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQIPHID
RCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGV
EAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMET
STSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFD
VLAKVPNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6hlr The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		R591 D629 D631
Binding residue
(residue number reindexed from 1)		R506 D544 D546
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hlr, PDBe:6hlr, PDBj:6hlr
PDBsum6hlr
PubMed30913026
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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