Structure of PDB 6hhm Chain A Binding Site BS01

Receptor Information
>6hhm Chain A (length=459) Species: 320324 (Formosa agariphila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQPNVLVFYVDDLRAELGCYGSKTAITPNIDKLATEGVQFNKAYVQQAIC
APSRMSTLTGLRPETLGIYSIFTPLRSVHKDVVSVPQLFKENGYKTVSIG
KVYHHGTDDKNQWTNYFTKEPNTYNKPENIALLEQFKKEGKKANGPAFEN
ADVADEAYKDGRAAKYAVETLKKLKNDKFIMFVGFSKPHLPFNAPKKYWD
LYDKNNFEIPERKKPENMYRLALTNWGELKGYHGIPNDVEYLDDNLTRDL
IHGYHASISYVDAQVGKVMEALEALGLRKNTTVIFMSDHGYKIGEYGAWC
KHSNEEIDVRVPLIVSRETSYKGRVAGKTSDALVENVDIFPTLVELCGLE
GPKTDGKSILQVIDRPNTPWDQVATAVYARGKNIMGCTATDGEWRYTEWR
DAKTQDILGAELYEHKNSLLSFKNLSGNTKYKKEEARMKGLLETQFPRNQ
GPFLQHDTP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6hhm Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hhm A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan.
Resolution1.23 Å
Binding residue
(original residue number in PDB)		D35 D36 C74 D312 H313
Binding residue
(residue number reindexed from 1)		D11 D12 C50 D288 H289
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D35 D36 C74 R78 K125 H128 F160 H213 D312 H313 K325
Catalytic site (residue number reindexed from 1) D11 D12 C50 R54 K101 H104 F136 H189 D288 H289 K301
Enzyme Commision number 3.1.6.-
Gene Ontology
Molecular Function
GO:0004423 iduronate-2-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6hhm, PDBe:6hhm, PDBj:6hhm
PDBsum6hhm
PubMed31285597
UniProtT2KPK5|PLH18_FORAG Ulvan-active sulfatase (Gene Name=BN863_22070)

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