Structure of PDB 6hft Chain A Binding Site BS01

Receptor Information
>6hft Chain A (length=312) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSINESL
YANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEE
AKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERENK
KIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMY
PTQDEFDFVGEVSELTTVQELVDLVLEGPQERFKKEGKENFTPKKVLVFM
ETKAGGLIKAGKKLTFHDILKKESPDVPLFDNALKIYIVPKVESEGWISK
WDKQKALERRSV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6hft Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hft The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		N235 L343 K344 K345 D349
Binding residue
(residue number reindexed from 1)		N162 L270 K271 K272 D276
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051879 Hsp90 protein binding

View graph for
Molecular Function
External links
PDB RCSB:6hft, PDBe:6hft, PDBj:6hft
PDBsum6hft
PubMed30876805
UniProtP33313|CNS1_YEAST Hsp70/Hsp90 co-chaperone CNS1 (Gene Name=CNS1)

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