Structure of PDB 6hcz Chain A Binding Site BS01

Receptor Information
>6hcz Chain A (length=65) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGETCADCGTILL
QDKQRKIYCVACQEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6hcz Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hcz Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C53 C56 C70 C73
Binding residue
(residue number reindexed from 1)		C42 C45 C59 C62
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0051301 cell division

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Molecular Function
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Biological Process
External links
PDB RCSB:6hcz, PDBe:6hcz, PDBj:6hcz
PDBsum6hcz
PubMed32170109
UniProtO60232|ZNRD2_HUMAN Protein ZNRD2 (Gene Name=ZNRD2)

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