Structure of PDB 6hc8 Chain A Binding Site BS01

Receptor Information
>6hc8 Chain A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEEL
IENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDE
KKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVG
RKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQN
FFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNF
QNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKR
IEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hc8 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339)
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y102 H199 D201 E202 Q203 R238 Q239 Y276 W296 A317 I318 N321 M325
Binding residue
(residue number reindexed from 1)		Y97 H194 D196 E197 Q198 R233 Q234 Y271 W291 A312 I313 N316 M320
Enzymatic activity
Enzyme Commision number 1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase.
1.14.11.n4: ankyrin-repeat-histidine dioxagenase.
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0019826 oxygen sensor activity
GO:0031406 carboxylic acid binding
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0036140 [protein]-asparagine 3-dioxygenase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
GO:0051213 dioxygenase activity
GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity
GO:0071532 ankyrin repeat binding
Biological Process
GO:0045663 positive regulation of myoblast differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045892 negative regulation of DNA-templated transcription
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:6hc8, PDBe:6hc8, PDBj:6hc8
PDBsum6hc8
PubMed
UniProtQ9NWT6|HIF1N_HUMAN Hypoxia-inducible factor 1-alpha inhibitor (Gene Name=HIF1AN)

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