Structure of PDB 6hb4 Chain A Binding Site BS01
Receptor Information
>6hb4 Chain A (length=197) Species:
9606
(Homo sapiens) [
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SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRK
Ligand information
>6hb4 Chain B (length=22) [
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ctgtgcagacattcaattgtta
Receptor-Ligand Complex Structure
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PDB
6hb4
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.
Resolution
3.05 Å
Binding residue
(original residue number in PDB)
L58 K62 L65 K69 T77 K139 R140 M143 K147 R157 Y162 Q179 L182 K183 K186 Y211 R232 R233 T234 K236
Binding residue
(residue number reindexed from 1)
L15 K19 L22 K26 T34 K96 R97 M100 K104 R114 Y119 Q136 L139 K140 K143 Y168 R189 R190 T191 K193
Binding affinity
PDBbind-CN
: Kd=4.4nM
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6hb4
,
PDBe:6hb4
,
PDBj:6hb4
PDBsum
6hb4
PubMed
31114891
UniProt
Q00059
|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)
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