Structure of PDB 6h8p Chain A Binding Site BS01
Receptor Information
>6h8p Chain A (length=346) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
NPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRAS
YDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCT
PRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILD
LVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSW
YSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFD
KVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSC
RKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>6h8p Chain C (length=6) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
ARKSAG
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
6h8p
Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.
Resolution
1.983 Å
Binding residue
(original residue number in PDB)
D135 N137 I168 E169 G170 Y175 Y177 K241 S288 N290 D311 V313
Binding residue
(residue number reindexed from 1)
D127 N129 I160 E161 G162 Y167 Y169 K233 S280 N282 D303 V305
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G162 Y169 H180 E182 H268 S280
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:6h8p
,
PDBe:6h8p
,
PDBj:6h8p
PDBsum
6h8p
PubMed
30156264
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
[
Back to BioLiP
]
