Structure of PDB 6h41 Chain A Binding Site BS01

Receptor Information
>6h41 Chain A (length=309) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDD
YETRITESKAVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPG
TSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYG
SWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRP
FDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKI
HNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWS
QPIYVGFSR
Ligand information
>6h41 Chain B (length=18) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VDECWRIIASHTWFCAEE
Receptor-Ligand Complex Structure
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PDB6h41 Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		Q25 K53 D55 Y57 K65 A66 V67 Y155 L184 R188 D189 W190
Binding residue
(residue number reindexed from 1)		Q19 K47 D49 Y51 K59 A60 V61 Y149 L178 R182 D183 W184
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004896 cytokine receptor activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6h41, PDBe:6h41, PDBj:6h41
PDBsum6h41
PubMed30529748
UniProtQ01344|IL5RA_HUMAN Interleukin-5 receptor subunit alpha (Gene Name=IL5RA)

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