Structure of PDB 6h1v Chain A Binding Site BS01

Receptor Information
>6h1v Chain A (length=1114) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVN
DVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLF
EARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDS
IKAERDCKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKKVLTF
DELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDT
VKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAH
KVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLE
LDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQY
QELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFN
EDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVC
NRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRL
GDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFL
RRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPR
VEHPDWLKRKIATK
Ligand information
Receptor-Ligand Complex Structure
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PDB6h1v Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P433 Q434 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1053 Y1059
Binding residue
(residue number reindexed from 1)		P375 Q376 D802 T803 K894 Y896 K909 G910 K914 R915 R916 S980 Y986
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h1v, PDBe:6h1v, PDBj:6h1v
PDBsum6h1v
PubMed30968138
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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