Structure of PDB 6h0e Chain A Binding Site BS01

Receptor Information

>6h0e Chain A (length=216) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PVQLVQSGAEVKKPGAPVKVSCETSGYRFSDYFVHWVRQAPGQGPEWIGR
IRPNSGGTKYAQKFQGRVTMTRDMSMNTAYMELSGLRSDDTAVYYCVRGH
CDGTTCSRAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPE
PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV
NHKPSNTKVDKRVEPK

Ligand information

>6h0e Chain I (length=9) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

MVDSPQLAT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6h0e Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Resolution	1.95 Å
Binding residue (original residue number in PDB)	S164 G165 A166
Binding residue (residue number reindexed from 1)	S158 G159 A160

External links

PDB	RCSB:6h0e, PDBe:6h0e, PDBj:6h0e
PDBsum	6h0e
PubMed	30001207

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