Structure of PDB 6gtc Chain A Binding Site BS01 |
| >6gtc Chain A (length=1280) Species: 401614 (Francisella tularensis subsp. novicida U112)
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MSIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKKA
KQIIDKYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFKS
AKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNGI
ELFKANSDITDIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSII
YRIVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAEELTFDIDYKT
SEVNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKGI
NEYINLYSQQINDKTLKKYKMSVLFKQILSDTDKLEDDSDVVTTMQSFYE
QIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSLTDLSQQVF
DDYSVIGTAVLEYITQQIAPKNQELIAKKTEKAKYLSLETIKLALEEFNK
HRDIDKQCRFEEILANFAAIPMIFDEIAQNKDNLAQISIKYQNQGKKDLL
QASAEDDVKAIKDLLDQTNNLLHKLKIFHISQSEDKANILDKDEHFYLVF
EECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENSTLANGWDKNKEP
DNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEGYKKIVYKLLPGA
NKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGSPQKGYEKFEFNIE
DCRKFIDFYKQSISKHPEWKDFGFRFSDTQRYNSIDEFYREVENQGYKLT
FENISESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNLHTLYWKALFDER
NLQDVVYKLNGEAELFYRKQSIPKKITHPAKEAIANKNKDNPKKESVFEY
DLIKDKRFTEDKFFFHCPITINFKSSGANKFNDEINLLLKEKANDVHILS
IDRGERHLAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKLAAIEKDRD
SARKDWKKINNIKEMKEGYLSQVVHEIAKLVIEYNAIVVFQDLNFGFKRG
RFKVEKQVYQKLEKMLIEKLNYLVFKDNEFDKTGGVLRAYQLTAPFETFK
KMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYESVSKSQEFFSKFDKI
CYNLDKGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFRNSNWDTREVY
PTKELEKLLKDYSIEYGHGECIKAAICGESDKKFFAKLTSVLNTILQMRN
SKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLKGLML
LGRIKNNQEGKKLNLVIKNEEYFEFVQNRN |
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| PDB | 6gtc Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. |
| Resolution | 3.91 Å |
Binding residue
(original residue number in PDB) | S14 T16 R18 K51 N185 P196 T197 K541 K589 Y591 K595 N790 K791 S797 R800 N802 L803 H804 E829 R833 H843 I849 A850 N851 K852 N853 N856 F863 Y865 L867 I868 K869 D870 K871 R872 F873 M949 K956 E979 G983 S986 Q987 H990 E1033 K1034 K1041 |
Binding residue
(residue number reindexed from 1) | S14 T16 R18 K51 N185 P196 T197 K526 K574 Y576 K580 N775 K776 S782 R785 N787 L788 H789 E814 R818 H828 I834 A835 N836 K837 N838 N841 F848 Y850 L852 I853 K854 D855 K856 R857 F858 M934 K941 E964 G968 S971 Q972 H975 E1018 K1019 K1026 |
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| Enzyme Commision number |
3.1.21.1: deoxyribonuclease I.
4.6.1.22: Bacillus subtilis ribonuclease. |
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