Structure of PDB 6gqd Chain A Binding Site BS01

Receptor Information
>6gqd Chain A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YTPFLANDHQHIRYNPLQDEWVLVSAHRMKRPWQGQLLKTVPRHDPLNPL
CPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAKSARG
VCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENK
GAMMGCSNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQ
ELLRKERLVLTSEHWLVLVPFWATWPYQTLLLPRRHVRRLPELTPAERDD
LASIMKKLLTKYDNLFETSFPYSMGWHGAPTGSEAGANWDHWQLHAHYYP
PLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHYHL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6gqd Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gqd Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L
Resolution1.523 Å
Binding residue
(original residue number in PDB)		E202 H301 H319 H321
Binding residue
(residue number reindexed from 1)		E178 H277 H295 H297
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N72 C75 S135 N173 S181 H184 H186 Q188
Catalytic site (residue number reindexed from 1) N48 C51 S111 N149 S157 H160 H162 Q164
Enzyme Commision number 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006011 UDP-glucose metabolic process
GO:0006012 galactose metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gqd, PDBe:6gqd, PDBj:6gqd
PDBsum6gqd
PubMed
UniProtP07902|GALT_HUMAN Galactose-1-phosphate uridylyltransferase (Gene Name=GALT)

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