Structure of PDB 6gpg Chain A Binding Site BS01

Receptor Information
>6gpg Chain A (length=651) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFKPRNYQLELALPAMKGKNTIICAPTGFGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASV
IATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKR
ICKDLNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHL
RKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQ
ELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKN
WIEGNPKLSFLKPGILTGDHNILIATSVADEGIDIAQCNLVILYEYVGNV
IKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTW
DEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTA
DVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSH
DWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPA
E
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6gpg Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Resolution2.894 Å
Binding residue
(original residue number in PDB)		K379 Q380 H381 Q507 Q511 N720 K750 H830 F853 K888 K907
Binding residue
(residue number reindexed from 1)		K141 Q142 H143 Q262 Q266 N449 K479 H559 F582 K617 K636
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6gpg, PDBe:6gpg, PDBj:6gpg
PDBsum6gpg
PubMed30047865
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

[Back to BioLiP]