Structure of PDB 6go6 Chain A Binding Site BS01

Receptor Information
>6go6 Chain A (length=359) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYHQYHRSHLADSAHNLRQRSS
TMDVFERSFCILKLDHGRVHSEEGKGWKAIRVDLVMCPYDRRAFALLGWT
GSRQFERDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLD
YIEPWERNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6go6 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		L189 N391 L392 R393 Q394 R455 R459 R462 R463 T466 H467 M472 R481
Binding residue
(residue number reindexed from 1)		L42 N244 L245 R246 Q247 R303 R307 R310 R311 T314 H315 M320 R329
Enzymatic activity
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6go6, PDBe:6go6, PDBj:6go6
PDBsum6go6
PubMed31138645
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt);
Q9JIW4|DPOLM_MOUSE DNA-directed DNA/RNA polymerase mu (Gene Name=Polm)

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