Structure of PDB 6gku Chain A Binding Site BS01

Receptor Information

>6gku Chain A (length=140) Species: 9606 (Homo sapiens)

SLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIV
FHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLK

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6gku Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6gku Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
• Resolution: 1.91 Å
• Binding residue (original residue number in PDB): N80 P82 Q107 S108 S109
• Binding residue (residue number reindexed from 1): N79 P81 Q106 S107 S108
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004622 lysophospholipase activity
• GO:0005515 protein binding
• GO:0030246 carbohydrate binding
• GO:0042802 identical protein binding
• GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

• GO:0002667 regulation of T cell anergy
• GO:0002724 regulation of T cell cytokine production
• GO:0046006 regulation of activated T cell proliferation
• GO:0070231 T cell apoptotic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0062023 collagen-containing extracellular matrix

External links

• PDB: RCSB:6gku, PDBe:6gku, PDBj:6gku
• PDBsum: 6gku
• PubMed: 31123109
• UniProt: Q05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)