Structure of PDB 6gkh Chain A Binding Site BS01
Receptor Information
>6gkh Chain A (length=685) Species:
10090
(Mus musculus) [
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ELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQAS
ESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVV
KSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVY
NNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEK
HILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKL
LEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHL
RKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDKSLKLDETDEF
LMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFT
KTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVI
SKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARA
DESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILE
LQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEK
MHHVNMTPEFKGLYIVRENQTNGEIICKCGQAWGTMMVHKGLDLPCLKIR
NFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
>6gkh Chain X (length=15) [
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gucaagccgaggaga
...............
Receptor-Ligand Complex Structure
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PDB
6gkh
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution
4.06 Å
Binding residue
(original residue number in PDB)
K451 E452 H759 T811 R843 M926 H927 N957 K983 K1002
Binding residue
(residue number reindexed from 1)
K146 E147 H434 T486 R518 M601 H602 N622 K648 K667
Enzymatic activity
Enzyme Commision number
3.6.4.13
: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003723
RNA binding
GO:0003724
RNA helicase activity
GO:0003725
double-stranded RNA binding
GO:0003727
single-stranded RNA binding
GO:0004386
helicase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0016887
ATP hydrolysis activity
GO:0019904
protein domain specific binding
GO:0038187
pattern recognition receptor activity
GO:0042802
identical protein binding
GO:0043021
ribonucleoprotein complex binding
GO:0046872
metal ion binding
Biological Process
GO:0002376
immune system process
GO:0009615
response to virus
GO:0016925
protein sumoylation
GO:0032727
positive regulation of interferon-alpha production
GO:0032728
positive regulation of interferon-beta production
GO:0032755
positive regulation of interleukin-6 production
GO:0032760
positive regulation of tumor necrosis factor production
GO:0039530
MDA-5 signaling pathway
GO:0045071
negative regulation of viral genome replication
GO:0045087
innate immune response
GO:0051259
protein complex oligomerization
GO:0051607
defense response to virus
GO:0060337
type I interferon-mediated signaling pathway
GO:0060760
positive regulation of response to cytokine stimulus
GO:0071360
cellular response to exogenous dsRNA
GO:0098586
cellular response to virus
GO:0140374
antiviral innate immune response
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
View graph for
Molecular Function
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Cellular Component
External links
PDB
RCSB:6gkh
,
PDBe:6gkh
,
PDBj:6gkh
PDBsum
6gkh
PubMed
30449722
UniProt
Q8R5F7
|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)
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