Structure of PDB 6gha Chain A Binding Site BS01

Receptor Information
>6gha Chain A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLG
MRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPELLAFLLDGLHE
DLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKS
TLVCPECAKISVTFDPFCYLTLPLASKVKLKDCIELFTTKEKLGAEDPWY
CPNCKEHQQATKKLDLWSLPPVLVVHLKRFSDKLDTLVDFPINDLDMSEF
LINPNAGPCRYNLIAVSNHYGGGGHYTAFAKNKDDGKWYYFDDSSVSTAS
EDQIVSKAAYVLFYQRQDTFSGTGF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6gha Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gha The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		C419 C422 C780
Binding residue
(residue number reindexed from 1)		C154 C157 C201
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6gha, PDBe:6gha, PDBj:6gha
PDBsum6gha
PubMed30228188
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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