Structure of PDB 6g9x Chain A Binding Site BS01

Receptor Information
>6g9x Chain A (length=396) Species: 335543 (Syntrophobacter fumaroxidans MPOB) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMPRWVPLLLGLLGSTTCGMLLYAWSVFIKPLNAESRAEIAMAFAICCLI
FGLMTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFIQSKYQLYITYGV
IAGFGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATYI
IEWRYVFWYCGVAMGIMALIAGAFLEPPPAGWKPAGAAPKVTRDWTYEEA
KGDTKFWLLYLAYFCGSFAGLMVIGHLAGFGRDAGLTAMAAAGAVSSLAF
SNAATRILSGWFVDKIGIRVYFAALFALQTAAMIAIFQLGGSVVGLSIVA
IVIGWNYGAMFTLFPATCLQFYGPTAQGSNYGLLFTACGLAGFAGPWVGG
WLKDTTGTYYLPFLCAAALCALGTAIVFMTKPPEKKHALELEVLFQ
Ligand information
Ligand IDJKE
InChIInChI=1S/C7H6O2S/c8-7(9)5-3-1-2-4-6(5)10/h1-4,10H,(H,8,9)
InChIKeyNBOMNTLFRHMDEZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC(=O)c1ccccc1S
OpenEye OEToolkits 1.7.0c1ccc(c(c1)C(=O)O)S
ACDLabs 12.01O=C(O)c1ccccc1S
FormulaC7 H6 O2 S
Name2-sulfanylbenzoic acid
ChEMBLCHEMBL119888
DrugBankDB14026
ZINCZINC000000284503
PDB chain6g9x Chain A Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6g9x Mechanistic basis of L-lactate transport in the SLC16 solute carrier family.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Y119 L145 R280 Y331 F335 C362
Binding residue
(residue number reindexed from 1)		Y110 L136 R256 Y307 F311 C338
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=3.92,Ki=120uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g9x, PDBe:6g9x, PDBj:6g9x
PDBsum6g9x
PubMed31201333
UniProtA0LNN5|SFMCT_SYNFM L-lactate transporter (Gene Name=Sfum_3364)

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