Structure of PDB 6g1s Chain A Binding Site BS01

Receptor Information
>6g1s Chain A (length=645) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGK
VIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYD
VIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIM
RRYLKQKLRNNDLKAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANL
DAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMASIQTYCQKS
PMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIR
MIDAYSHLETFYTDEKEKKFAVLNDETDEFLMNLFFDNKKMLKKLAENPK
EKLIKLRNTILEQFTRSSRGIIFTKTRQSTYALSQWIMENAKVKAHHLIG
AGHSSEVKPMTQTEQKEVISKFRTINLLIATTVAGLDIKECNIVIRYGLV
TNEIAMVQARGRARADESTYVLVTSSGVTEREIVNDFREKMMYKAINRVQ
NMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSM
LVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKTNGEIICKCGQAWGTMM
VHKGLDLPCLKIRNFVVNFSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g1s Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution3.93 Å
Binding residue
(original residue number in PDB)		K451 A453 H578 Q581 T767 T769 N812 H927
Binding residue
(residue number reindexed from 1)		K142 A144 H259 Q262 T411 T413 N452 H565
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6g1s, PDBe:6g1s, PDBj:6g1s
PDBsum6g1s
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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