Structure of PDB 6g0a Chain A Binding Site BS01

Receptor Information
>6g0a Chain A (length=1104) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVG
WLTNMHATLVSQETNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDE
SRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNS
NQLFEARKLLRPILQDNARNIYNVDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFRDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKKKVLTFDEL
SYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKS
FRDRRYEFKGLAKTWKGNLSKHARDEAKKMIVLYDSLQLAHKVILNSFYG
YVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCI
LPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNY
IYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELK
GFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDS
HGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMV
KDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSL
EDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKR
KIAT
Ligand information
Receptor-Ligand Complex Structure
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PDB6g0a Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		P433 Q434 G435 R749 V750 D875 T876 K967 Y969 K982 G983 K987 R988 R989 S1051 S1053 Y1059
Binding residue
(residue number reindexed from 1)		P374 Q375 G376 R673 V674 D793 T794 K885 Y887 K900 G901 K905 R906 R907 S969 S971 Y977
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g0a, PDBe:6g0a, PDBj:6g0a
PDBsum6g0a
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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