Structure of PDB 6g07 Chain A Binding Site BS01
Receptor Information
>6g07 Chain A (length=245) Species:
9606
(Homo sapiens) [
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YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLSKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
Ligand information
>6g07 Chain P (length=9) Species:
9606
(Homo sapiens) [
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TLLQLLLGH
Receptor-Ligand Complex Structure
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PDB
6g07
Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
Resolution
1.66 Å
Binding residue
(original residue number in PDB)
K336 Q346 Q349 I350 P500 L501 E504
Binding residue
(residue number reindexed from 1)
K73 Q83 Q86 I87 P237 L238 E241
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004879
nuclear receptor activity
Biological Process
GO:0006355
regulation of DNA-templated transcription
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Cellular Component
External links
PDB
RCSB:6g07
,
PDBe:6g07
,
PDBj:6g07
PDBsum
6g07
PubMed
29990434
UniProt
P51449
|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)
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