Structure of PDB 6fz6 Chain A Binding Site BS01

Receptor Information
>6fz6 Chain A (length=341) Species: 479434 (Sphaerobacter thermophilus DSM 20745) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PMALYDLTLAELEERLAADGVPRYRARQIFHWAYRQLAVDYDAMTVLPKT
LRADLATRLPLTPLTPVREVQTDDGETIKTLFRTVDGQHIETVLMFYPDR
TTVCVSCQVGCAVGCSFCATGMMGLTRNLTAGEMVAQVVAAARRAREAGR
TLTNIVMMGMGEPFQNYEATMRMVRILHEEEGMNFGARRITVSTSGLVPF
IDRLAREPFQVKLAVSLHAPNDDLRSSLVPLNRRYPIGELIAACRRYVGE
TGRRVTFEYVLIDGVNDSDANAEELARLLRGLLCHVNLIPLNPTPAAPFG
RPSVERINRFEQILRARGIPATVRYSRGVDISAACGQLRAE
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6fz6 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fz6 Crystal Structure of a radical SAM methyltransferase from Sphaerobacter thermophilus
Resolution1.42 Å
Binding residue
(original residue number in PDB)		C110 V112 C114 C117 G120 G160 S194
Binding residue
(residue number reindexed from 1)		C111 V113 C115 C118 G121 G161 S195
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.192: 23S rRNA (adenine(2503)-C(2))-methyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0002935 tRNA (adenine(37)-C2)-methyltransferase activity
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0019843 rRNA binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0070040 rRNA (adenine(2503)-C2-)-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fz6, PDBe:6fz6, PDBj:6fz6
PDBsum6fz6
PubMed
UniProtD1C4T7

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