Structure of PDB 6fws Chain A Binding Site BS01

Receptor Information
>6fws Chain A (length=686) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MALTAALKAQIAAWYKALQEQIPDFIPRAPQRQMIADVAKTLAGEEGRHL
AIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIYSKDLPLL
KKIIPDLKFTAAFGRGRYVCPRNLTALASTEPTQQDLLAFLDDELTPNNQ
EEQKRCAKLKGDLDTYKWDGLRDHTDIAIDDDLWRRLSTECPFFVARREI
QEAEVVVANHALVMAAMESEAVLPDPKNLLLVLDEGHHLPDVARDALEMS
AEITAPWYRLQLDLFTKLVATCMEQFRPKTIPPLAIPERLNAHCEELYEL
IASLNNILNLYMPAGQEAEHRFAMGELPDEVLEICQRLAKLTEMLRGLAE
LFLNDLSEKTDIVRLHRLILQMNRALGMFEAQSKLWRLASLAQSSGAPVT
KWATREEREGQLHLWFHCVGIRVSDQLERLLWRSIPHIIVTSATLRSLNS
FSRLQEMSGLKEKAGDRFVALDSPFNHCEQGKIVIPRMRVEPSIDNEEQH
IAEMAAFFREQVESKKHLGMLVLFASGRAMQRFLDYVTDLRLMLLVQGDQ
PRYRLVELHRKRVANGERSVLVGLQSFAEGLDLKGDLLSQVHIHKIAFPP
IDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHGCWGEV
VIYDKRLLTKNYGKRLLDALPVFPIEQPEVPEGIVK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fws DNA translocation mechanism of an XPD family helicase.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		N85 V86 G114 R115 R117 N223 A225 L226 S543 R545 Q564 R569 S593 F615 P617 D619 Y636 F638 E639 K677 Y679
Binding residue
(residue number reindexed from 1)		N85 V86 G114 R115 R117 N209 A211 L212 S526 R528 Q547 R552 S576 F598 P600 D602 Y619 F621 E622 K660 Y662
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0033677 DNA/RNA helicase activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0009432 SOS response
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:6fws, PDBe:6fws, PDBj:6fws
PDBsum6fws
PubMed30520735
UniProtP27296|DING_ECOLI ATP-dependent DNA helicase DinG (Gene Name=dinG)

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