Structure of PDB 6fhi Chain A Binding Site BS01

Receptor Information

>6fhi Chain A (length=709) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKENDDDNAMLKHRFEIIEGQERNIAWTIVNSICNMTEN
SKPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSF
DGEEMATDDEYILDEESRARIKTRLFVLRQELATALEEEFSYPPTFQRLA
NQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPRTI
RELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDTFW
GWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKWGL
GEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELTNS
NWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTALL
NSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVVNF
ISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTNGT
SKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNRENDWP
IGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLLIQ
AFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSMGS
GSGENLYFQ

Ligand information

>6fhi Chain R (length=13)

uauaccucugcuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6fhi Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): M472 H505 L506 R507 K567
• Binding residue (residue number reindexed from 1): M457 H490 L491 R492 K552

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting

External links

• PDB: RCSB:6fhi, PDBe:6fhi, PDBj:6fhi
• PDBsum: 6fhi
• UniProt: H6QM92