Structure of PDB 6ff5 Chain A Binding Site BS01
Receptor Information
>6ff5 Chain A (length=104) Species:
9913
(Bos taurus) [
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GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFSYTD
ANKNKGITWGEETLMEYLENPKKYIPGTKMIFAGIKKKGEREDLIAYLKK
ATNE
Ligand information
Ligand ID
HEC
InChI
InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,9-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;+4/b21-7?,22-8?,26-13-,29-14-,30-15-,31-16-;
InChIKey
HXQIYSLZKNYNMH-LJNAALQVSA-N
SMILES
Software
SMILES
ACDLabs 10.04
O=C(O)CCC1=C(C2=CC6=C(C(=C/C)\C5=CC4=C(C(\C3=Cc7c(c(c8C=C1N2[Fe](N34)(N56)n78)CCC(=O)O)C)=C/C)C)C)C
OpenEye OEToolkits 1.5.0
CC=C1C(=C2C=C3C(=CC)C(=C4N3[Fe]56N2C1=Cc7n5c(c(c7C)CCC(=O)O)C=C8N6C(=C4)C(=C8CCC(=O)O)C)C)C
CACTVS 3.341
C\C=C1/C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)\C7=C/C)C=C1N2[Fe@@]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
CACTVS 3.341
CC=C1C(=C2C=C3N4C(=Cc5n6c(C=C7N8C(=C(C)C7=CC)C=C1N2[Fe]468)c(C)c5CCC(O)=O)C(=C3C)CCC(O)=O)C
Formula
C34 H34 Fe N4 O4
Name
HEME C
ChEMBL
DrugBank
ZINC
PDB chain
6ff5 Chain A Residue 201 [
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Receptor-Ligand Complex Structure
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PDB
6ff5
X-ray structure of bovine heart cytochrome c at high ionic strength.
Resolution
1.74 Å
Binding residue
(original residue number in PDB)
K13 C14 C17 H18 G29 P30 G41 Y48 T49 N52 W59 Y67 T78 K79 M80 I81 F82
Binding residue
(residue number reindexed from 1)
K13 C14 C17 H18 G29 P30 G41 Y48 T49 N52 W59 Y67 T78 K79 M80 I81 F82
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0009055
electron transfer activity
GO:0020037
heme binding
GO:0046872
metal ion binding
Biological Process
GO:0006122
mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006123
mitochondrial electron transport, cytochrome c to oxygen
GO:0006915
apoptotic process
Cellular Component
GO:0005739
mitochondrion
GO:0005758
mitochondrial intermembrane space
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6ff5
,
PDBe:6ff5
,
PDBj:6ff5
PDBsum
6ff5
PubMed
29516298
UniProt
P62894
|CYC_BOVIN Cytochrome c (Gene Name=CYCS)
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