Structure of PDB 6fb3 Chain A Binding Site BS01

Receptor Information
>6fb3 Chain A (length=1836) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGMFDLVANGGSS
LTLHFERAPFMSQERTVWLPWNSFYAMDTLVMPSCDLSGFVRPDPVIISS
PLSTFFSDAPGRNPIVPETQVLHEEIEVPGSSIKLIYLSSRTAGYKSLLK
IIMTQSLVPLNLIKVHLMVAVEGHLFQKSFLASPNLAYTFIWDKTDAYGQ
KVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKH
HVLNVKSGILHKGNGENQFLTQQPAVITSIMGNGRRRSISCPSCNGLAEG
NKLLAPVALAVGIDGSLFVGDFNYIRRIFPSRNVTSILELRNKEFKHSNN
PAHKYYLAVDPVSGSLYVSDTNSRRIYKVKSLTGTKDLAGNSEVVAGTGE
QCLPFDEARCGDGGKAVDATLMSPRGIAVDKYGLMYFVDATMIRKVDQNG
IISTLLGSNDLTAVRPLSCDSSMDVSQVRLEWPTDLAVDPMDNSLYVLEN
NVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISH
TGVLYISETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGD
DGYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNRPILNSFNQYE
AASPGEQELYVFNADGIHQYTLSLVTGEYLYNFTYSSDNDVTEVMDSNGN
SLKVRRDASGMPRHLLMPDNQIVTLAVGTNGGLKLVSTQTLELGLMTYNG
NSGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITID
IENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGM
SISFHSEPHVLAGTVTPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTV
FGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQLGRPFLWLP
SSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIISRMFADGKVWSY
TYLEKSMVLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSVGYIR
NIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYD
STAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGM
VNARFDYTYHDNSFRIASIKPIISETPLPVDLYRYDEISGKVEHFGKFGV
IYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGR
VTKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHL
LNPGNSVRLMPLRYDLRDRITRLGDIPYKIDDDGFLCQRGSDVFEYNSKG
LLTRAYNKANGWNVQYRYDGLGRRASCKTNLGHHLQYFYADLHNPTRVTH
VYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGL
MIKQLQYTAYGEIYYDSNPDFQLVIGFHGGLYDPLTKLVHFTQRDYDVLA
GRWTSPDYTMWKNIGREPAPFNLYMFKSNNPLSNELDLKNYVTDVKSWLV
MFGFQLSNIIPGFPRAKMYFVSPPYELTESQACENGQLITGVQQTTERHN
QAFMALEGQVISKRLHASIREKAGHWFATSTPIIGKGIMFAVKKGRVTTG
ISSIATDDSRKIASVLNSAHYLEKMHYSIEGKDTHYFVKIGSADSDLVTL
AMTSGRKVLDSGVNVTVSQPTLLINGRTRRFTNIEFQYSTLLINIRYGLT
ADTLDEEKARVLDQARQRALGSAWAKEQQKARDGREGSRVWTDGEKQQLL
NTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNE
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain6fb3 Chain E Residue 5 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fb3 Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		S2429 N2430
Binding residue
(residue number reindexed from 1)		S1467 N1468
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6fb3, PDBe:6fb3, PDBj:6fb3
PDBsum6fb3
PubMed29540701
UniProtQ9DER5|TEN2_CHICK Teneurin-2 (Gene Name=TENM2)

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