Structure of PDB 6f6d Chain A Binding Site BS01
Receptor Information
>6f6d Chain A (length=450) Species:
9606
(Homo sapiens) [
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ESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN
WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESHIIKFGTNIDLSDAK
RWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTP
GHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWW
PILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPL
TAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKF
CLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFV
TSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAP
Ligand information
>6f6d Chain B (length=17) Species:
9606
(Homo sapiens) [
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RIQLMTKAARKSAPATG
Receptor-Ligand Complex Structure
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PDB
6f6d
Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity.
Resolution
1.81811 Å
Binding residue
(original residue number in PDB)
E1244 R1246 E1269 S1270 R1272 N1331 D1333 L1371 G1372 Q1377 G1435 N1484 Q1564 V1567 Y1573 T1597 Y1598
Binding residue
(residue number reindexed from 1)
E88 R90 E113 S114 R116 N143 D145 L183 G184 Q189 G247 N296 Q376 V379 Y385 T409 Y410
Enzymatic activity
Enzyme Commision number
1.14.11.68
: [histone H3]-trimethyl-L-lysine(27) demethylase.
External links
PDB
RCSB:6f6d
,
PDBe:6f6d
,
PDBj:6f6d
PDBsum
6f6d
PubMed
29220567
UniProt
O15054
|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)
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