Structure of PDB 6f42 Chain A Binding Site BS01

Receptor Information
>6f42 Chain A (length=1398) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPKPIRGFCQRLKGKQGRFRGNLSG
KRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGD
VVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLH
VPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSF
YDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNS
PVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLG
DGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLL
SKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISG
NRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGRE
GLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDG
LDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPL
EERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKF
LEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLGVPRIKEIINASKVI
STPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQV
RIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFP
ENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRD
VMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDP
RHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFY
MKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFES
Ligand information
>6f42 Chain X (length=43) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
actattttcggctactataaataaatgtttttttcgcaatagt
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f42 Molecular mechanism of promoter opening by RNA polymerase III.
Resolution5.5 Å
Binding residue
(original residue number in PDB)		E210 R213
Binding residue
(residue number reindexed from 1)		E203 R206
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6f42, PDBe:6f42, PDBj:6f42
PDBsum6f42
PubMed29345638
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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